Search Result
Results for "
<i>Schisandra lancifolia<_i> (Rehd. et Wils.) A. C. Smith
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N0860
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Schizantherin-E
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Others
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Inflammation/Immunology
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Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.
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- HY-N11939
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HIV
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Infection
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Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC50=2.23 μg/mL .
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- HY-N10030
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Others
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Others
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11-O-Syringylbergenin is a bergenin derivative isolated from the whole plants of Corylopsis willmottiae Rehd. et Wils
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- HY-N6047
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Others
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Others
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Lancifodilactone C is a Triterpenoids product that can be isolated from the herbs of Schisandra lancifolia .
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- HY-N2293
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Others
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Others
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Chamigrenal is a natural product that can be extract from the fruits of Schisandra sphenanthera .
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- HY-N11944
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Others
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Others
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Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .
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- HY-N3512
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Others
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Cancer
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Wilfornine A is a natural product that can be isolated from Schisandra sphenanthera. Wilfornine A has anti-tumor effect .
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- HY-N12790
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Ananonin B
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Glycosidase
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Metabolic Disease
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Arisanschinin D (Ananonin B) is an α-Glucosidase inhibitor and can be isolated from Schisandra arisanensis Hay .
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- HY-N2870
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SchisanWilsonin N
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Others
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Others
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Angeloylisogomisin O is a compound isolated from the aerial parts of Schisandra propinqua var. propinqua .
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- HY-N6048
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HIV
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Infection
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Lancifodilactone F (compound 1) can be isolated from the leaves and stems of Schisandra lancifolia. Lancifodilactone F has anti-HIV activity with EC50=20.69 μg/mL. Lancifodilactone F has cytotoxicity against C8166 cells (CC50 >200 μg/mL) .
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- HY-N2245
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CD74
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Cancer
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Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .
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- HY-N11172
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Others
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Neurological Disease
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Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata .
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- HY-145889
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Others
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Others
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LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
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- HY-N0691
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Schizandrin; Schizandrol; Schizandrol-A
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Autophagy
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Inflammation/Immunology
Cancer
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Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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- HY-N0691R
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Autophagy
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Inflammation/Immunology
Cancer
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Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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- HY-N3832
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(-)-Epinortrachelogenin
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Others
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Others
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Epinortrachelogenin ((-)-Epinortrachelogenin) is a natural lignan found in the plateau medicinal plant Daphne acutiloba Rehd .
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- HY-N12065
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Others
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Others
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Parisyunnanoside H is a steroidal saponin isolated from Paris polyphylla Smith var. yunnanensis .
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- HY-N3984
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Others
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Others
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Gynuramide II is a Cerebrosides product that can be isolated from the herbs of Exochorda racemosa (Lindl.) Rehd .
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- HY-113435
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- HY-122969
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Others
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Cancer
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Anwuweizonic acid is a natural compound, isolated from Schisandra propinqua. Anwuweizonic acid is the putative anticancer active principle of Schisandra propinqua .
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- HY-N2691
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Others
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Others
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6,8-Cyclo-1,4-eudesmanediol is a Sesquiterpenoids product that can be isolated from the branches of Eucalyptus robusta Smith .
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- HY-N12046
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HIV
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Infection
Inflammation/Immunology
Cancer
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Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .
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- HY-N12047
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HIV
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Infection
Inflammation/Immunology
Cancer
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Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .
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- HY-N12425
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Others
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Others
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Heteroclitin A is a lignan isolated from the stems of Schisandra propinqua.
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- HY-115836
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Dihydrofolate reductase (DHFR)
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Cancer
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DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM .
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- HY-N2222
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- HY-N5044
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Arisanschinin L
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Others
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Others
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Schisanwilsonin B is a lignan from the fruits of Schisandra wilsoniana .
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- HY-N12714
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Others
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Others
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Interiorin C is the key active ingredient and key bioactivity marker in Schisandra chinensis (K. Interiorin) that is directly related to the improvement of hematopoietic function. Modern pharmacological research attributes Schisandra chinensis's blood-tonifying effects to its antioxidant and immunomodulatory activities .
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- HY-N10805
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Others
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Others
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Schisanlignone C is a chemical component of Schisandra viridis a. c. sm .
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- HY-N10806
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Others
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Others
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Schisanlignone D is a chemical component of Schisandra viridis a. c. sm .
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- HY-N11936
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Others
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Others
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Rubriflorin B is a lignan that can be isolated from Schisandra rubriflora .
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- HY-N12048
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Others
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Others
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Schisandrathera D is a lignan that can be isolated from Schisandra sphenanthera .
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- HY-N11947
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Others
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Others
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Schisanligone B is a lignan isolated from Schisandra chinensis seeds .
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- HY-N2271
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- HY-N8622A
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Others
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Others
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Heteroclitin B is a saturated dibenzocyclooctene lignan isolated from the stems of Schisandra chinensis.
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- HY-N3437
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Others
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Others
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Kadsuric acid is a Triterpenoids product that can be isolated from the fruits of Schisandra sphenanthera .
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- HY-N11917
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Others
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Others
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Schisantherin S is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .
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- HY-N11971
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Others
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Others
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Yunnankadsurin B is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .
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- HY-N4284
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NSC 382182
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Others
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Others
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Angelicolide (NSC 382182) is a Phenols product that can be isolated from the herbs of Schisandra propinqua .
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- HY-N7958
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Others
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Others
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Gomisin F is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .
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- HY-N3481
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Others
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Others
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Isogomisin O is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .
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- HY-N0859
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Schizanhenol; Gomisin-K3
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UGT
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Cancer
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Schisanhenol is a natural compound solated from Schisandra rubriflora; UGT2B7 UDP-glucuronosyltransferases inhibitor.
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- HY-N1539
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19-epi-Arisanlactone D; 22-O-Acetylarisanlactone C; 24,25-Dihydropreschisanartanin
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Others
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Others
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Preschisanartanin B (compound 9) is a preschisanartane-type nortriterpenoid. Preschisanartanin B can be isolated from the Schisandra arisanensis .
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- HY-N2209
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PPAR
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Metabolic Disease
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Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ .
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- HY-N8260
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Others
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Neurological Disease
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Angeloylgomisin Q is a new dibenzocyclooctadiene lignan from the stems of Schisandra sphaerandra . Angeloylgomisin Q has the potential for alzheimer's disease research .
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- HY-N4100
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TNF Receptor
HIV
SGLT
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Infection
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Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd , Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope . Neuroprotective effects . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells .
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- HY-N0089
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- HY-N2267
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Reactive Oxygen Species
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Inflammation/Immunology
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(+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .
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- HY-N2270
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p38 MAPK
ERK
IKK
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Inflammation/Immunology
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Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .
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- HY-N2266
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COX
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Inflammation/Immunology
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Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity .
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- HY-N12333
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Others
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Others
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4,4-Di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol is a Phenols product that can be isolated from the herbs of Schisandra propinqua .
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- HY-N4100R
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TNF Receptor
HIV
SGLT
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Infection
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Trilobatin (Standard) is the analytical standard of Trilobatin. This product is intended for research and analytical applications. Trilobatin, a natural sweetener derived from?Lithocarpus polystachyus?Rehd , Trilobatin?is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope . Neuroprotective effects . Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells .
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- HY-N6866
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Apoptosis
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Neurological Disease
Inflammation/Immunology
Cancer
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Gomisin N, isolated from Schisandra chinensis. Gomisin N has the potential for use in the treatment of allergy. Gomisin N is an anti-cancer agent candidate capable of inhibiting the proliferation and inducing the apoptosis in cancer .
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- HY-122935
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HIV
Reverse Transcriptase
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Infection
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Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .
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- HY-N7543
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HIV
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Infection
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Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects .
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- HY-N0089R
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Autophagy
Reactive Oxygen Species
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Neurological Disease
Cancer
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Schisandrin B (Standard) is the analytical standard of Schisandrin B. This product is intended for research and analytical applications. Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
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- HY-N2413
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UGT
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Metabolic Disease
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Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule .
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- HY-16911
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AFN-1252
Maximum Cited Publications
8 Publications Verification
API-1252; Debio 1452
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Bacterial
Antibiotic
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Infection
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AFN-1252 is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 exhibits typical MIC90 values of ⩽0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .
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- HY-N2264
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Influenza Virus
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Infection
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Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus H1N1 and H1N1-TR (a Tamiflu agent resistant virus strain) activities .
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- HY-N3963
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(+)-Gomisin M2
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HIV
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Infection
Neurological Disease
Inflammation/Immunology
Cancer
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Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC50 of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .
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- HY-114622
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API-1252 tosylate; Debio 1452 tosylate
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Bacterial
Antibiotic
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Infection
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AFN-1252 (API-1252) tosylate is an orally active and selective inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 tosylate exhibits exquisite and highly selective activity against Staphylococcus spp. AFN-1252 tosylate exhibits typical MIC90 values of ?0.015 μg/ml against diverse clinical isolates of S. aureus. AFN-1252 tosylate is efficacious in a mouse model of septicemia providing 100% protection from an otherwise lethal peritoneal infection of S. aureus Smith .
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- HY-N0692
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Gomisin-A; TJN-101; Wuweizi alcohol-B
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Reactive Oxygen Species
Cytochrome P450
Autophagy
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Cancer
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Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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- HY-N0692R
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Reactive Oxygen Species
Cytochrome P450
Autophagy
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Cancer
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Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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- HY-16638
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PDDF
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Thymidylate Synthase
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Metabolic Disease
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CB 3717 is a potent inhibitor of human thymidylate synthetase, competitively binding with 5,10-methylenetetrahydrofolate (Ki = 4.9 X 10(-9) M). It also competitively inhibits human dihydrofolate reductase with dihydrofolate (Ki = 2.3 X 10(-8) M). In WI-L2 human lymphoblastoid cells, CB 3717 treatment led to a significant decrease in cellular dTTP levels and a notable increase in dUMP levels, indicating a disruption in nucleotide metabolism. The growth-inhibitory effect of CB 3717 was reversed by thymidine supplementation, demonstrating that thymidylate synthetase became rate-limiting in the presence of this compound. Delayed thymidine supplementation beyond 8 hours resulted in severe cytotoxicity, underscoring the critical timing of nucleotide rescue strategies in CB 3717-treated cells .
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- HY-N0385
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AMPK
Calcium Channel
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Cardiovascular Disease
Metabolic Disease
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Gomisin J is a small molecular weight lignan found in Schisandra chinensis and has been demonstrated to have vasodilatory activity . Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca 2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells. gomisin J has potential benefits in treating nonalcoholic fatty liver disease .
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- HY-118129
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Ganwuweizic acid
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PARP
Apoptosis
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Cancer
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Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects .
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- HY-W414548
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Others
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Neurological Disease
Metabolic Disease
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7α,27-Dihydroxycholesterol is an oxysterol characterized by its oxidized side chains and is produced through the hydroxylation of 27-Hydroxycholesterol (27-OHC); it serves as a metabolite of interest in lipidomic analyses of various pathological conditions, including neurological diseases, Smith-Lemli-Opitz syndrome, obesity metabolic syndrome, and diabetes. Notably, levels of 7α,27-di-OHC decrease following lipopolysaccharide activation, and it also functions as a ligand for Epstein-Barr virus-induced gene 2 (EBI2). Additionally, 7α,27-di-OHC exists as a structural isomer of 7α,25-dihydroxycholesterol (7α25-OHC).
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- HY-N2896
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Reactive Oxygen Species
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Inflammation/Immunology
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Arjunolic acid is a saponin isolated from Cyclocarya paliurus and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species .
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- HY-B0766
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SY801
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Autophagy
Apoptosis
HBV
HCV
HSP
Reactive Oxygen Species
Bcl-2 Family
Glutathione S-transferase
p38 MAPK
NF-κB
Microtubule/Tubulin
ERK
JNK
TNF Receptor
Interleukin Related
CDK
Cyclin G-associated Kinase (GAK)
mTOR
P-glycoprotein
Ferroptosis
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Infection
Inflammation/Immunology
Cancer
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Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .
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